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Proteintech
MVP/LRP Polyclonal Antibody
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Product Details
16478-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MVP/LRP Fusion Protein Ag9593 (544-893 aa encoded by BC015623)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: NWHFEVNDR KDPQETAKLF SVPDFVGDAC KAIASRVRGA VASVTFDDFH KNSARIIRTA VFGFETSEAK GPDGMALPRP RDQAVFPQNG LVVSSVDVQS VEPVDQRTRD ALQRSVQLAI EITTNSQEAA AKHEAQRLEQ EARGRLERQK ILDQSEAEKA RKELLELEAL SMAVESTGTA KAEAESRAEA ARIEGEGSVL QAKLKAQALA IETEAELQRV QKVRELELVY ARAQLELEVS KAQQLAEVEV KKFKQMTEAI GPSTIRDLAV AGPEMQVKLL QSLGLKSTLI TDGSTPINLF NTAFGLLGMG PEGQPLGRRV ASGPSPGEGI SPQSAQAPQA PGDNHVVPVL R (544-893 aa encoded by BC015623)
Target Information
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: lrp; Lung resistance-related protein; Major vault protein; MVP; MVP1; Testicular Secretory Protein Li 30; unnamed protein product; VAULT1; vRNP
Gene Aliases: 2310009M24Rik; LRP; MVP; VAULT1
UniProt ID: (Human) Q14764, (Rat) Q62667, (Mouse) Q9EQK5
Entrez Gene ID: (Human) 9961, (Rat) 64681, (Mouse) 78388
cell proliferation
protein transport
negative regulation of protein autophosphorylation
ERBB signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
mRNA transport
negative regulation of protein tyrosine kinase activity
protein activation cascade
negative regulation of signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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