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Invitrogen
MX1 Polyclonal Antibody
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FIGURE: 1 / 6
MX1 Antibody (PA5-22149) in IHC (P)
MX1 Antobody detects MX1 protein at cytosol on MDA-MB-468 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded MDA-MB-468 xenograft. MX1 Antobody (Product # PA5-22149) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-22149
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Rodent
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human MX1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.06 mg/mL
Amount
6 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: NCI-H929, human MX1-transfected 293T.
Predicted reactivity: Mouse (83%), Dog (85%), Pig (83%), Sheep (80%), Rhesus Monkey (96%), Chimpanzee (99%), Bovine (84%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: IFI-78K; Interferon-induced GTP-binding protein Mx1; Interferon-induced protein p78; interferon-inducible protein p78; Interferon-regulated resistance GTP-binding protein MxA; Myxoma resistance protein 1; myxovirus (influenza virus) resistance 1, interferon-inducible protein p78; Myxovirus resistance protein 1; p78 protein; unnamed protein product
Gene Aliases: IFI-78K; IFI78; lncMX1-215; MX; MX1; MxA
UniProt ID: (Human) P20591
Entrez Gene ID: (Human) 4599
immune system process
apoptotic process
defense response
signal transduction
response to virus
synaptic vesicle budding from presynaptic endocytic zone membrane
response to type I interferon
negative regulation of viral genome replication
innate immune response
defense response to virus
interleukin-27-mediated signaling pathway
antiviral innate immune response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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