|Immunocytochemistry (ICC)||2 µg/ml|
|Immunofluorescence (IF)||2 µg/ml|
|Western Blot (WB)||Assay Dependent|
|Immunoprecipitation (IP)||See 1 publications below|
|Western Blot (WB)||See 1 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Human Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from the C-terminal region of the human MYBBP1A|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
The Myb family of transcription factors, which includes the structurally related A-, B-, and c-Myb genes, regulate differentiation, cellular growth and transactivating gene expression. c-Myb plays an essential role in controlling the proliferation and differentiation of hematopoietic cells, cellular levels of c-Myb decreasing as cells reach terminal differentiation. Myb-binding protein 1A (MYBBP1A) is a novel nuclear protein localized predominantly, but not exclusively, in nucleoli. Although initially isolated as a c-Myb-interacting protein, MYBBP1A is expressed ubiquitously, and associates with a number of different transcription factors. MYBBP1A associates with the aromatic hydrocarbon receptor (AhR), enhancing transactivation and increasing AhR-dependent gene expression. MYBBP1A is a powerful negative regulator of PPAR gamma coactivator 1 alpha (PGC-1 alpha) by p38 MAPK and also acts as a nucleocytoplasmic shuttling protein that utilizes CRM1-dependent and independent nuclear export pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MYB binding protein (P160) 1a; Myb-binding protein 1A; P160; p53-activated protein-2
Gene Aliases: MYBBP1A; P160; PAP2
UniProt ID: (Human) Q9BQG0
Entrez Gene ID: (Human) 10514
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