Immunogen sequence: TGDSDEWVFD KKLLCETEGR VRVETTKDRS IFTVEGAEKE DEGVYTVTVK NPVGEDQVNL TVKVIDVPDA
MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008].
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Protein Aliases: C-protein, cardiac muscle isoform; Cardiac MyBP-C; CMH4; FHC; MYBP-C; Myosin-binding protein C, cardiac-type; truncated cardiac myosin-binding protein C
Gene Aliases: CMD1MM; CMH4; FHC; LVNC10; MYBP-C; MYBPC3
UniProt ID: (Human) Q14896
Entrez Gene ID: (Human) 4607