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Proteintech
MYCBP2 Polyclonal Antibody
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Product Details
27951-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MYCBP2 Fusion Protein Ag27228 (2672-2880 aa encoded by NM_015057)
Conjugate
Form
Liquid
Concentration
0.67 mg/mL
Amount
100.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGNSKGDRG NISTSSKPAS TSGKSELSSK HSRSLKPDGR MSRTTADQKK PRGTESLSAS ESLILKSDAA KLRSDSHSRS LSPNHNTLQT LKSDGRMPSS SRAESPGPGS RLSSPKPKTL PANRSSPSGA SSPRSSSPHD KNLPQKSTAP VKTKLDPPRE RSKSDSYTLD PDTLRKKKMP LTEPLRGRST SPKPKSVPKD STDSPGSENR A (2672-2880 aa encoded by NM _015057)
Target Information
This gene encodes an E3 ubiquitin-protein ligase and member of the PHR (Phr1/MYCBP2, highwire and RPM-1) family of proteins. The encoded protein plays a role in axon guidance and synapse formation in the developing nervous system. In mammalian cells, this protein regulates the cAMP and mTOR signaling pathways, and may additionally regulate autophagy. Reduced expression of this gene has been observed in acute lymphoblastic leukemia patients and a mutation in this gene has been identified in patients with a rare inherited vision defect.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase MYCBP2; Highwire; MYC binding protein 2, E3 ubiquitin protein ligase; Myc-binding protein 2; PAM/Highwire/RPM-1 protein 1; PAM; nuclear; contains RCC1 repeats; Protein associated with Myc; RING-type E3 ubiquitin transferase MYCBP2; unnamed protein product
Gene Aliases: KIAA0916; Myc-bp2; MYCBP2; PAM; Phr; PHR1
UniProt ID: (Human) O75592
Entrez Gene ID: (Human) 23077
axon guidance
motor neuron axon guidance
regulation of synaptic growth at neuromuscular junction
protein ubiquitination
branchiomotor neuron axon guidance
central nervous system projection neuron axonogenesis
positive regulation of protein ubiquitination
regulation of protein localization
circadian regulation of gene expression
negative regulation of protein catabolic process
rhythmic process
cell morphogenesis involved in neuron differentiation
neuromuscular process
regulation of cytoskeleton organization
axon development
protein K48-linked ubiquitination
regulation of axon guidance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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