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Proteintech
MYCN Polyclonal Antibody
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Product Details
10159-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MYCN Fusion Protein Ag0193 (289-464 aa encoded by BC002712)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Amount
52.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SNTKAVTTF TITVRPKNAA LGPGRAQSSE LILKRCLPIH QQHNYAAPSP YVESEDAPPQ KKIKSEASPR PLKSVIPPKA KSLSPRNSDS EDSERRRNHN ILERQRRNDL RSSFLTLRDH VPELVKNEKA AKVVILKKAT EYVHSLQAEE HQLLLEKEKL QARQQQLLKK IEHARTC (289-464 aa encoded by BC002712 )
Target Information
N-Myc protein is member of the MYC family of transcription factor proteins with a basic helix-loop-helix (bHLH) domain. N-Myc is similarly regulated and functionally complementary to C-Myc in the context of various cellular growth and differentiation processes. MYCN gene is considered the hallmark of neuroblastoma, amplification and overexpression of the MYCN proto-oncogene occurs in approximately 20% of neuroblastomas and is associated with advanced stage disease, rapid tumor progression, and poor prognosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc); Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc); bHLHe37; Class E basic helix-loop-helix protein 37; N-myc proto-oncogene protein; neuroblastoma MYC oncogene; neuroblastoma myc-related oncogene 1; neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene; oncogene NMYC; oncogene pp65/67; unnamed protein product; v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog; v-myc myelocytomatosis viral related oncogene, neuroblastoma derived
Gene Aliases: BHLHE37; c-nmyc; FGLDS1; MODED; MPAPA; MYCN; MYCNsORF; MYCNsPEP; N-myc; Nmuc1; NMYC; Nmyc-1; Nmyc1; ODED
UniProt ID: (Human) P04198, (Mouse) P03966, (Rat) Q63379
Entrez Gene ID: (Human) 4613, (Mouse) 18109, (Rat) 298894
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
kinase binding
protein dimerization activity
sequence-specific double-stranded DNA binding
basic helix-loop-helix transcription factor
cartilage condensation
positive regulation of mesenchymal cell proliferation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell proliferation
positive regulation of gene expression
negative regulation of gene expression
lung development
embryonic digit morphogenesis
positive regulation of programmed cell death
regulation of auditory receptor cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic skeletal system morphogenesis
astrocyte differentiation
negative regulation of astrocyte differentiation
branching morphogenesis of an epithelial tube
epithelial cell proliferation
positive regulation of epithelial cell proliferation
autosome genomic imprinting
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of reactive oxygen species metabolic process
positive regulation of cell proliferation
positive regulation of cell death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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