Immunogen sequence: ARMKQLKRQL EEAEEEATRA NASRRKLQRE LDDATEANEG LSREVSTLKN RLRRGGPISF SSSRSGRRQL HLEGASLELS DDDTESKTSD VNETQPPQSE; Positive Samples: HepG2, NIH/3T3, HT-29, Mouse brain, Mouse kidney, Rat brain; Cellular Location: Cell projection, lamellipodium
MYH10 encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Cellular myosin heavy chain, type B; flectin; MCH-B(B2); Myosin heavy chain 10; myosin heavy chain 10, non-muscle; Myosin heavy chain, non-muscle IIb; myosin heavy chain, nonmuscle type B; myosin heavy chain, nonmuscular, type B; myosin IIB; myosin, heavy polypeptide 10, non-muscle; Myosin-10; NMMHC II-b; NMMHC-B; NMMHC-IIB; Non-muscle myosin heavy chain B; Non-muscle myosin heavy chain IIb; nonmuscle myosin heavy chain II-B; nonmuscle myosin heavy chain IIB; nonmuscle myosin heavy chain-B; nonmuscle myosin II heavy chain-B
Gene Aliases: 5730504C04Rik; 9330167F11Rik; Fltn; MCH-B; mKIAA3005; MYH10; Myhn-2; Myhn2; NMHC II-B; NMHC-B; NMHCII-B; NMMHC II-b; NMMHC-B; NMMHC-IIB; NMMHCB; SMemb