This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.
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Protein Aliases: beta cardiac myosin heavy chain; beta myosin heavy chain; beta-myosin-heavy-chain; cardiac muscle myosin heavy chain 7 beta; cardiac myosin heavy chain beta isoform; CMD1S; CMH1; MPD1; MYH-beta/slow; MyHC-beta; MyHC-slow; MYHCB; myopathy, distal 1; myosin 7; myosin beta heavy chain; Myosin heavy chain 7; myosin heavy chain polypeptide 7 cardiac muscle fetal; Myosin heavy chain slow isoform; myosin heavy chain slow type 1 (beta cardiac); Myosin heavy chain, cardiac muscle beta isoform; myosin heavy chain, cardiac muscle, fetal; myosin heavy chain, polypeptide 7; myosin, heavy chain 7, cardiac muscle, beta; myosin, heavy polypeptide 7, cardiac muscle, beta; Myosin-7; rhabdomyosarcoma antigen MU-RMS-40.7A; SPMD; SPMM; type slow/beta myosin heavy chain; ventricular myosin heavy chain
Gene Aliases: B-MHC; beta-MHC; BOS_10147; CMD1S; CMH1; mg:cb02g011; MPD1; MYH7; Myhc-b; MyHC-I; MYHCB; smyhc3; SPMD; SPMM; vmhc