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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • MYH9 Antibodies

          Proteintech

          MYH9 Polyclonal Antibody

          37 References
          View all (37) MYH9 antibodies
          Datasheet
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          Datasheet
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          Questions & Answers

          Cite MYH9 Polyclonal Antibody

          • Antibody Testing Data (16)
          MYH9 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          MYH9 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 16

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          MYH9 Antibody (11128-1-AP) in ICC/IF

          Immunofluorescent analysis of ( -20°C Ethanol ) fixed HepG2 cells using 11128-1-AP (MYH9 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          MYH9 Antibody in Immunocytochemistry (ICC/IF)
          MYH9 Antibody in Immunocytochemistry (ICC/IF)
          MYH9 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MYH9 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MYH9 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MYH9 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MYH9 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MYH9 Antibody in Western Blot (WB)
          MYH9 Antibody in Western Blot (WB)
          MYH9 Antibody in Western Blot (WB)
          MYH9 Antibody in Western Blot (WB)
          MYH9 Antibody in Western Blot (WB)
          MYH9 Antibody in Western Blot (WB)
          MYH9 Antibody in Western Blot (WB)
          MYH9 Antibody in Flow Cytometry (Flow)
          MYH9 Antibody in Immunoprecipitation (IP)

          Product Details

          11128-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          View 16 publications 16 publications

          Immunohistochemistry (IHC)

          -
          View 5 publications 5 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:20-1:200
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:500
          View 11 publications 11 publications

          Flow Cytometry (Flow)

          Assay-dependent
          -

          Immunoprecipitation (IP)

          0.5-4.0 µg
          View 5 publications 5 publications
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          MYH9 Fusion Protein Ag1612 (1741-1960 aa encoded by BC011915)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.19 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: EQGNTELIN DRLKKANLQI DQINTDLNLE RSHAQKNENA RQQLERQNKE LKVKLQEMEG TVKSKYKASI TALEAKIAQL EEQLDNETKE RQAACKQVRR TEKKLKDVLL QVDDERRNAE QYKDQADKAS TRLKQLKRQL EEAEEEAQRA NASRRKLQRE LEDATETADA MNREVSSLKN KLRRGDLPFV VPRRMARKGA GDGSDEEVDG KADGAEAKPA E (1741-1960 aa encoded by BC011915)

          Target Information

          The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton that plays essential roles in various cellular processes. Structurally, the MYH9 gene spans over 106 kilobases and includes 41 exons that translate into a protein of 1,960 amino acids. This protein is a part of a hexameric complex, which includes two heavy chains, two regulatory light chains, and two essential light chains. The NMHC IIA protein interacts with actin filaments and is involved in cellular activities such as cell migration, adhesion, division, and maintenance of cell shape. Functionally, mutations in MYH9 can result in a spectrum of autosomal dominant disorders collectively known as MYH9-related diseases (MYH9-RD), which include conditions such as May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome. These disorders are primarily characterized by macrothrombocytopenia (abnormally large platelets) and may lead to other complications such as hearing loss, renal failure, and cataracts later in life. MYH9 is also crucial in hematopoiesis, where its proper function is necessary for the survival and maintenance of hematopoietic stem and progenitor cells (HSPCs). Loss of MYH9 function disrupts normal hematopoiesis, leading to severe blood cell deficiencies and bone marrow failure.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: Cellular myosin heavy chain, type A; flectin; MGC104539; Myosin heavy chain 9; myosin heavy chain IX; Myosin heavy chain, non-muscle IIa; myosin IIA; Myosin-9; myosin-9-like; myosin9; NMHC II-A; NMHC-II A; NMMHC II-a; NMMHC IIA; NMMHC-A; non-muscle myosin heavy chain 9; Non-muscle myosin heavy chain A; Non-muscle myosin heavy chain IIa; non-muscle myosin heavy polypeptide 9; nonmuscle myosin heavy chain II-A

          View more View less

          Gene Aliases: BDPLT6; DFNA17; EPSTS; Fltn; FTNS; MHA; MYH9; Myhn-1; Myhn1; NMHC-II-A; NMHCIIA; NMMHC-A; NMMHC-IIA; NMMHCA; TU72.6

          View more View less

          UniProt ID: (Human) P35579, (Mouse) Q8VDD5

          View more View less

          Entrez Gene ID: (Rat) 100911597, (Human) 4627, (Mouse) 17886

          View more View less

          Function(s)
          microfilament motor activity motor activity actin binding ATP binding ATPase activity actin-dependent ATPase activity protein homodimerization activity protein anchor ADP binding poly(A) RNA binding actin filament binding protein binding calmodulin binding protein domain specific binding cadherin binding involved in cell-cell adhesion nucleotide binding
          Process(es)
          meiotic spindle organization cell morphogenesis involved in differentiation cytokinesis angiogenesis in utero embryonic development establishment of T cell polarity membrane protein ectodomain proteolysis phagocytosis, engulfment movement of cell or subcellular component cell adhesion myoblast fusion regulation of cell shape protein transport single organismal cell-cell adhesion actin filament polymerization actin filament-based movement platelet formation actomyosin structure organization actin cytoskeleton reorganization uropod organization blood vessel endothelial cell migration establishment of meiotic spindle localization actin filament capping platelet aggregation negative regulation of actin filament severing positive regulation of protein processing in phagocytic vesicle integrin-mediated signaling pathway monocyte differentiation leukocyte migration metabolic process
          It has to be done as per old AB suggested Products section.
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