Keep as concentrated solution.
Positive Control: 293T, A431, HeLa, HepG2, MYH9-EGFP-transfected 293T.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate -gamma-secretase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BDPLT6 antibody; Cellular myosin heavy chain, type A; DFNA17 antibody; EPSTS antibody; FTNS antibody; heavy chain 9; MHA antibody; myosin; Myosin heavy chain 9; Myosin heavy chain, non-muscle IIa; Myosin-9; NMHC-II A antibody; NMMHC II-a; NMMHC IIA antibody; NMMHC-A; NMMHCA antibody; non-muscle antibody; non-muscle myosin heavy chain 9; Non-muscle myosin heavy chain A; Non-muscle myosin heavy chain IIa; non-muscle myosin heavy polypeptide 9; nonmuscle myosin heavy chain II-A
Gene Aliases: BDPLT6; DFNA17; EPSTS; FTNS; MHA; MYH9; NMHC-II-A; NMMHC-IIA; NMMHCA
UniProt ID: (Human) P35579
Entrez Gene ID: (Human) 4627