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Proteintech
MYO18A Polyclonal Antibody
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Product Details
14611-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MYO18A Fusion Protein Ag6185 (1601-2002 aa encoded by BC039612)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Amount
25.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TLSDQVNRR DFESEKRLRK DLKRTKALLA DAQLMLDHLK NSAPSKREIA QLKNQLEESE FTCAAAVKAR KAMEVEIEDL HLQIDDIAKA KTALEEQLSR LQREKNEIQN RLEEDQEDMN ELMKKHKAAV AQASRDLAQI NDLQAQLEEA NKEKQELQEK LQALQSQVEF LEQSMVDKSL VSRQEAKIRE LETRLEFERT QVKRLESLAS RLKENMEKLT EERDQRIAAE NREKEQNKRL QRQLRDTKEE MGELARKEAE ASRKKHELEM DLESLEAANQ SLQADLKLAF KRIGDLQAAI EDEMESDENE DLINSEGDSD VDSELEDRVD GVKSWLSKNK GPSKAASDDG SLKSSSPTSY WKSLAPDRSD DEHDPLDNTS RPRYSHSYLS DSDTEAKLTE TNA (1601-2002 aa encoded by BC039612)
Target Information
MYO18A may link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 12 kDa TGF-beta-1-induced antiapoptotic factor; KIAA0216; MAJN; molecule associated with Jak-3 N-terminal; Molecule associated with JAK3 N-terminus; myosin 18A; Myosin containing a PDZ domain; myosin containing PDZ domain; myosin XVIIIb; myosin; SP-R210aS; SP-A receptor SP-R210 short isoform; Putative TGFB1-induced anti-apoptotic factor 1; SP-A receptor subunit SP-R210 alphaS; SP-R210; Surfactant protein receptor SP-R210; TGF-beta-1-induced antiapoptotic factor 1; TGFB1-induced anti-apoptotic factor 1; Unconventional myosin-XVIIIa; unnamed protein product
Gene Aliases: CD245; KIAA0216; MAJN; MYO18A; MyoPDZ; MYSPDZ; SP-R210; SPR210; TIAF1
UniProt ID: (Human) Q92614, (Mouse) Q9JMH9
Entrez Gene ID: (Human) 399687, (Rat) 360570, (Mouse) 360013
DNA metabolic process
apoptotic process
Golgi organization
I-kappaB kinase/NF-kappaB signaling
cell migration
actomyosin structure organization
regulation of macrophage activation
negative regulation of apoptotic process
Golgi vesicle budding
positive regulation of protein secretion
Golgi ribbon formation
asymmetric Golgi ribbon formation
positive regulation of opsonization
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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