MYO18A may link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking.
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Protein Aliases: MAJN; Molecule associated with JAK3 N-terminus; myosin 18A; Myosin containing a PDZ domain; myosin containing PDZ domain; myosin XVIIIb; myosin-XVIIIa; SP-A receptor subunit SP-R210 alphaS; SP-R210; Surfactant protein receptor SP-R210; Unconventional myosin-XVIIIa
Gene Aliases: CD245; KIAA0216; MAJN; MYO18A; MyoPDZ; MYSPDZ; SPR210