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Invitrogen
MYO18A Polyclonal Antibody
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FIGURE: 1 / 1
MYO18A Antibody (PA5-97178) in WB
Western blot analysis of MYO18A in extracts of various cell lines. Samples were incubated with MYO18A Polyclonal antibody (Product # PA5-97178) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-97178
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1970-2054 of human MYO18A (NP_5108802)
Conjugate
Form
Liquid
Concentration
2.04 mg/mL
Amount
204 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SDVDSELEDR VDGVKSWLSK NKGPSKAASD DGSLKSSSPT SYWKSLAPDR SDDEHDPLDN TSRPRYSHSY LSDSDTEAKL TETNA; Positive Samples: U-251MG, HeLa, Jurkat, Mouse brain, Mouse liver, Rat brain; Cellular Location: Cytoplasm, Endoplasmic reticulum-Golgi intermediate compartment, Golgi apparatus, cytoskeleton, trans-Golgi network
Target Information
MYO18A may link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 12 kDa TGF-beta-1-induced antiapoptotic factor; KIAA0216; MAJN; molecule associated with Jak-3 N-terminal; Molecule associated with JAK3 N-terminus; myosin 18A; Myosin containing a PDZ domain; myosin containing PDZ domain; myosin XVIIIb; myosin; SP-R210aS; SP-A receptor SP-R210 short isoform; Putative TGFB1-induced anti-apoptotic factor 1; SP-A receptor subunit SP-R210 alphaS; SP-R210; Surfactant protein receptor SP-R210; TGF-beta-1-induced antiapoptotic factor 1; TGFB1-induced anti-apoptotic factor 1; Unconventional myosin-XVIIIa; unnamed protein product
Gene Aliases: CD245; KIAA0216; MAJN; MYO18A; MyoPDZ; MYSPDZ; SP-R210; SPR210; TIAF1
UniProt ID: (Human) Q92614, (Mouse) Q9JMH9
Entrez Gene ID: (Human) 399687, (Rat) 360570, (Mouse) 360013
DNA metabolic process
apoptotic process
Golgi organization
I-kappaB kinase/NF-kappaB signaling
cell migration
actomyosin structure organization
regulation of macrophage activation
negative regulation of apoptotic process
Golgi vesicle budding
positive regulation of protein secretion
Golgi ribbon formation
asymmetric Golgi ribbon formation
positive regulation of opsonization
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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