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Product Details
PA5-61844
| Applications | Tested Dilution | Publications |
|---|---|---|
Immunohistochemistry (IHC) |
1:200-1:500 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant protein corresponding to Human MYO3A |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.2, with 40% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2644370 |
Product Specific Information
Immunogen sequence: IIIQSAARGH LVRKQRKEIV DMKNTAVTTI QTSDQEFDYK KNFENTRESF VKKQAENAIS ANERFISAPN NKGSVSVVKT STFKPEEETT NAV
Highest antigen sequence identity to the following orthologs: Mouse - 57%, Rat - 55%.
Target Information
The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins and unconventional myosins based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Myosin-IIIa
Gene Aliases: DFNB30; MYO3A
UniProt ID: (Human) Q8NEV4
Entrez Gene ID: (Human) 53904
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