Recommended positive controls: rat and chicken cerebellum, rat brain.
PA1-24947 will not react with mouse.
This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Dilute myosin heavy chain, non-muscle; dilute-opisthotonus; MYH12; MYO5; myosin 5A; Myosin heavy chain p190; myosin I heavy chain isoform; myosin VA (heavy chain 12, myoxin); myosin VA (heavy polypeptide 12, myoxin); Myosin-V; myosin-Va; MYR12; Unconventional myosin-Va
Gene Aliases: D; DILUTE; Dop; Myh12; MYO5A; myoxin); non-muscle