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Invitrogen
MYO5A Polyclonal Antibody
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FIGURE: 1 / 2
MYO5A Antibody (PA5-101689) in ICC/IF
Immunocytochemistry analysis of MYO5A in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with MYO5A polyclonal antibody (Product # PA5-101689) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-101689
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MYO5A(Accession Q9Y4I1), corresponding to amino acid residues L1783-P1833.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MYO5A.
Target Information
This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: actin-associated molecular motor; alternatively spliced; molecular motor; dilute lethal-20J protein; Dilute myosin heavy chain, non-muscle; dilute-opisthotonus; flailer; motor protein; myosin 5a; Myosin heavy chain 12; myosin V; myosin VA (heavy chain 12, myoxin); myosin, heavy polypeptide kinase; Myosin-12; myosin-Va; Myoxin; OTTMUSP00000017756; OTTMUSP00000019176; OTTMUSP00000046608; Unconventional myosin-Va; unnamed protein product
Gene Aliases: 9630007J19Rik; AI413174; AI661011; D; d-120J; Dbv; Dilute; Dop; flail; flr; GS1; MVa; MYH12; MYO5; MYO5A; MyoVA; MYR12; Sev-1
UniProt ID: (Human) Q9Y4I1, (Mouse) Q99104, (Rat) Q9QYF3
Entrez Gene ID: (Human) 4644, (Mouse) 17918, (Rat) 25017
microfilament motor activity
nucleotide binding
RNA binding
motor activity
actin binding
catalytic activity
protein binding
calmodulin binding
ATP binding
ATPase activity
small GTPase binding
actin filament binding
SNARE binding
calcium ion binding
syntaxin-1 binding
Rab GTPase binding
ATP-dependent protein binding
poly(A) RNA binding
protein heterodimerization activity
protein dimerization activity
calcium-dependent protein binding
actin binding motor protein
post-Golgi vesicle-mediated transport
endocytosis
actin filament organization
protein transport
vesicle-mediated transport
actin filament-based movement
vesicle transport along actin filament
melanosome transport
cellular response to insulin stimulus
protein localization to plasma membrane
regulation of Golgi organization
melanin metabolic process
transport
exocytosis
chemical synaptic transmission
visual perception
metabolic process
regulation of exocytosis
insulin secretion
melanocyte differentiation
regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
locomotion involved in locomotory behavior
secretory granule localization
melanosome localization
odontogenesis
myelination
anagen
long-chain fatty acid biosynthetic process
pigmentation
developmental pigmentation
synapse organization
neuromuscular process controlling balance
endoplasmic reticulum localization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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