Immunogen sequence: AQALAQSERK RHELNRQVTV QRKEKDFQGM LEYHKEDEAL LIRNLVTDLK PQMLSGTVPC LPAYILYMCI RHADYTNDDL KVHSLLTSTI NGIKKVLKKH NDDFEMTSFW LSNTCRLLHC LKQYSGDEGF MTQNTAKQNE HCLKNFDLTE YRQVLSDLSI QIYQQLIKIA EGVLQPMIVS AMLENESIQG LSGVKPTGYR KRSSSMADGD NSYCLEAIIR QMNAFHTVMC DQGLDPEIIL QVFKQLFYMI N; Positive Samples: SKOV3, SW480; Cellular Location: Cytoplasm
May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis.
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Protein Aliases: MYO5B variant protein; myosin-Vb; Unconventional myosin-Vb
Gene Aliases: AI661750; KIAA1119; mKIAA1119; MYO5B
UniProt ID: (Human) Q9ULV0