This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: celiac disease 4; myosin; myosin-IXb; myr 5; Unconventional myosin from rat 3; unconventional myosin IXb; Unconventional myosin-9b; Unconventional myosin-IXb
Gene Aliases: CELIAC4; MYO9B; MYR5
UniProt ID: (Human) Q13459