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Invitrogen
MYO9B Polyclonal Antibody
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Product Details
PA5-101688
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MYO9B(Accession Q13459), corresponding to amino acid residues S303-F353.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MYO9B.
Target Information
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: celiac disease 4; myosin; myosin-IXb; myr 5; Unconventional myosin from rat 3; Unconventional myosin-9b; Unconventional myosin-IXb; unnamed protein product
Gene Aliases: CELIAC4; MYO9B; MYR5
UniProt ID: (Human) Q13459
Entrez Gene ID: (Human) 4650, (Mouse) 17925, (Rat) 25486
microfilament motor activity
nucleotide binding
motor activity
actin binding
GTPase activator activity
protein binding
calmodulin binding
ATP binding
zinc ion binding
ATPase activity
small GTPase binding
protein homodimerization activity
ADP binding
metal ion binding
Roundabout binding
actin filament binding
actin-dependent ATPase activity
ATP-dependent protein binding
signal transduction
Rho protein signal transduction
actin filament-based movement
ARF protein signal transduction
regulation of Rho protein signal transduction
Roundabout signaling pathway
intracellular signal transduction
regulation of small GTPase mediated signal transduction
lamellipodium morphogenesis
monocyte chemotaxis
metabolic process
establishment of cell polarity
actin-myosin filament sliding
positive regulation of GTPase activity
macrophage chemotaxis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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