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Product Details
PA5-67810
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human MYOCD.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2692213
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Basic SAP coiled-coil transcription activator 2; Myocardin; SRF co-factor protein (cardiac and smooth muscle); SRF cofactor protein; transcription factor myocardin
Gene Aliases: Bsac2; BSAC2A; MYCD; MYOCD; Srfcp
UniProt ID: (Human) Q8IZQ8, (Mouse) Q8VIM5, (Rat) Q8R5I7
Entrez Gene ID: (Human) 93649, (Mouse) 214384, (Rat) 246297
core promoter sequence-specific DNA binding
transcription factor activity, RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription coactivator activity
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
protein binding
transcription factor binding
histone acetyltransferase binding
histone deacetylase binding
R-SMAD binding
transcription coactivator activity
molecular_function
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of cell growth by extracellular stimulus
vasculogenesis
response to hypoxia
cardiac ventricle development
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
transcription from RNA polymerase II promoter
positive regulation of cell proliferation
negative regulation of cell proliferation
negative regulation of cardiac muscle cell apoptotic process
negative regulation of myotube differentiation
positive regulation of transforming growth factor beta receptor signaling pathway
cardiocyte differentiation
regulation of histone acetylation
hepatic stellate cell activation
vascular smooth muscle cell differentiation
positive regulation of DNA binding
cellular component maintenance
regulation of myoblast differentiation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle contraction
lung alveolus development
digestive tract development
positive regulation of sequence-specific DNA binding transcription factor activity
smooth muscle cell differentiation
regulation of smooth muscle cell differentiation
positive regulation of smooth muscle cell differentiation
cardiac muscle cell differentiation
ventricular cardiac muscle cell differentiation
uterus development
urinary bladder development
cell growth involved in cardiac muscle cell development
cellular response to growth factor stimulus
cellular response to hypoxia
ductus arteriosus closure
negative regulation of beta-amyloid clearance
regulation of phenotypic switching
positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
positive regulation of cardiac vascular smooth muscle cell differentiation
positive regulation of cardiac muscle cell differentiation
negative regulation of skeletal muscle cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
heart development
muscle cell differentiation
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