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Invitrogen

MYOCD Polyclonal Antibody

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MYOCD Polyclonal Antibody

Product Details

PA5-95700

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 680-780 of human MYOCD (NP_7058321)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.77 mg/mL

Amount

77 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2807502

Product Specific Information

Positive Samples: Rat heart; Cellular Location: Nucleus

Immunogen sequence: SQVCTAQMAG LHSSDKVGPK FSIPSPTFSK SSSAISEVTQ PPSYEDAVKQ QMTRSQQMDE LLDVLIESGE MPADAREDHS CLQKVPKIPR SSRSPTAVLT K

Target Information

Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Myocardin; MYOCD-B; transcription factor; SRF-binding; transcription factor myocardin; unnamed protein product

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Gene Aliases: MGBL; MYCD; MYOCD

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UniProt ID: (Human) Q8IZQ8, (Rat) Q8R5I7

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Entrez Gene ID: (Human) 93649, (Rat) 246297

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Function(s)
transcription coactivator activity protein binding histone acetyltransferase binding histone deacetylase binding RNA polymerase II sequence-specific DNA binding transcription factor binding R-SMAD binding DNA-binding transcription factor binding core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding molecular_function transcription factor binding DNA-binding transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter regulation of cell growth by extracellular stimulus vasculogenesis response to hypoxia cardiac ventricle development chromatin organization regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter heart development positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of gene expression cardiac muscle cell apoptotic process negative regulation of cardiac muscle cell apoptotic process negative regulation of myotube differentiation positive regulation of transforming growth factor beta receptor signaling pathway cardiocyte differentiation vascular smooth muscle cell differentiation cellular component maintenance regulation of myoblast differentiation positive regulation of gene expression, epigenetic positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle contraction lung alveolus development digestive tract development smooth muscle cell differentiation regulation of muscle cell differentiation regulation of smooth muscle cell differentiation positive regulation of smooth muscle cell differentiation cardiac muscle cell differentiation ventricular cardiac muscle cell differentiation uterus development urinary bladder development negative regulation of cell adhesion molecule production cardiac muscle cell myoblast differentiation cardiac vascular smooth muscle cell differentiation ductus arteriosus closure negative regulation of beta-amyloid clearance regulation of phenotypic switching positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of vascular smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell migration negative regulation of platelet-derived growth factor receptor-beta signaling pathway positive regulation of cardiac muscle cell differentiation negative regulation of skeletal muscle cell differentiation positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation regulation of histone acetylation hepatic stellate cell activation muscle cell differentiation positive regulation of DNA binding negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of sequence-specific DNA binding transcription factor activity cell growth involved in cardiac muscle cell development cellular response to growth factor stimulus cellular response to hypoxia positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation positive regulation of cardiac vascular smooth muscle cell differentiation
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