|Flow Cytometry (Flow)||1:10-1:50|
|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 111-139 amino acids from the N-terminal region of human MYSM1|
|Purification||Antigen affinity chromatography|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 2A-DUB; 2ADUB; Histone H2A deubiquitinase MYSM1; myb-like; Myb-like, SWIRM and MPN domain-containing protein 1; Myb-like, SWIRM and MPN domains 1; RP4-592A1.1; SWIRM and MPN domain-containing protein 1
Gene Aliases: 2A-DUB; 2ADUB; C130067A03Rik; C530050H10Rik; KIAA1915; MYSM1
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