Immunogen sequence: VNCIGRIHTY LELIGAINFG CEQAVYNRPQ TVDKVRIRDR KDAVEAYQLA QRLQSMRTRR RRVRDPWGNW CDAKDLEGQT FEHLS
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 2A-DUB; Deubiquitinase MYSM1; Myb-like, SWIRM and MPN domain-containing protein 1; Myb-like, SWIRM and MPN domains 1; RP4-592A1.1
Gene Aliases: 2A-DUB; 2ADUB; KIAA1915; MYSM1
UniProt ID: (Human) Q5VVJ2
Entrez Gene ID: (Human) 114803
Molecular Function: chromatin/chromatin-binding, or -regulatory protein