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MYT1L Polyclonal Antibody
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Product Details
600-401-CX0
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti- MYT1L antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid peptide near the C-terminus of human MYT1L.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
MYT1L, myelin transcription factor 1 family, to which the myelin transcription factor 1-like protein (MYT1L) belongs, is expressed primarily in the developing central nervous system and recruits histone deacetylase (HDAC) to regulate neural transcription. Both MYT1L and the related protein MYT1 interact with SIN3B, a protein that mediates transcriptional repression by binding to HDACs, suggesting that the MYT1 family favor the silencing of genes during neural development. Recent studies suggest that polymorphisms of MYT1L may be associated with schizophrenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Myelin transcription factor 1-like protein; MyT1-L; Neural zinc finger factor 1; neural zinc finger protein NZF-1; neural zinc finger transcription factor 1; NZF-1; postmeiotic neural gene 1; Postmitotic neural gene 1 protein; unnamed protein product; Zinc finger protein Png-1
Gene Aliases: 2900046C06Rik; 2900093J19Rik; C630034G21Rik; KIAA1106; mKIAA1106; MRD39; myT1-L; MYT1L; Nzf-1; NZF1; Nztf1; Pmng1; Png-1; Png1; ZC2H2C2; ZC2HC4B
UniProt ID: (Human) Q9UL68, (Mouse) P97500, (Rat) P70475
Entrez Gene ID: (Human) 23040, (Mouse) 17933, (Rat) 116668
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
zinc ion binding
retinoic acid-responsive element binding
metal ion binding
cobalt ion binding
metal ion sequestering activity
RNA polymerase II transcription coactivator activity
protein binding
zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
cell differentiation
neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
neuron fate commitment
neuron fate specification
neuron development
transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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