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          • Primary Antibodies ›
          • MeCP2 Isoform 2 Antibodies

          Fabgennix

          MeCP2 isoform 2 Polyclonal Antibody, FITC

          View all (3) MeCP2 Isoform 2 antibodies

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          Cite MeCP2 isoform 2 Polyclonal Antibody, FITC

          Additional Information:

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          MeCP2 isoform 2 Polyclonal Antibody, FITC

          Product Details

          MECP2-FITC

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:1,000
          -

          Immunohistochemistry (IHC)

          1:50-1:250
          -

          ELISA (ELISA)

          1:10,000
          -

          Immunoprecipitation (IP)

          1:50-1:250
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic peptide taken within amino acid region 436-486 on Methyl-CpG-binding protein 2 isoform 2 protein.
          3D Epitope / Immunogen

          Conjugate

          FITC FITC FITC

          Excitation/Emission Max

          498/517 nm View spectra spectra

          Form

          Liquid

          Concentration

          0.5-1.5 mg/mL

          Purification

          Affinity chromatography

          Storage buffer

          proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C, store in dark

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: MeCP-2; meCP-2 protein; MECP2; MECP2A; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_1; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_2; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_3; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_5; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_6; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_7; methyl CpG binding protein 2 (Rett syndrome) isoform MECP2_8; Rett Syndrome transcript 1; Rett syndrome; MECP2B; transcript variant; transcriptional repressor; involved in Rett syndrome disease; unnamed protein product

          View more View less

          Gene Aliases: 1500041B07Rik; AUTSX3; D630021H01Rik; Mbd5; MECP2_e1; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT; WBP10

          View more View less

          UniProt ID: (Human) P51608, (Rat) Q00566, (Mouse) Q9Z2D6

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          Entrez Gene ID: (Human) 4204, (Rat) 29386, (Mouse) 17257

          View more View less

          Function(s)
          nucleic acid binding DNA binding chromatin binding transcription corepressor activity RNA binding mRNA binding protein binding methyl-CpG binding double-stranded methylated DNA binding siRNA binding binding, bridging histone reader activity molecular condensate scaffold activity promoter-specific chromatin binding four-way junction DNA binding enzyme binding protein domain specific binding chromatin DNA binding identical protein binding histone deacetylase binding unmethylated CpG binding
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter Notch signaling pathway associative learning gene expression negative regulation of gene expression negative regulation of angiogenesis neuron differentiation regulation of gene expression, epigenetic negative regulation of blood vessel endothelial cell migration hypermethylation of CpG island negative regulation of transcription, DNA-templated cell development negative regulation of developmental process negative regulation of smooth muscle cell differentiation regulation of multicellular organismal process genetic imprinting positive regulation of microtubule nucleation axo-dendritic protein transport protein localization to presynapse behavioral fear response response to hypoxia startle response neurological system process involved in regulation of systemic arterial blood pressure regulation of respiratory gaseous exchange by neurological system process ventricular cardiac muscle tissue development inositol metabolic process regulation of transcription from RNA polymerase II promoter glutamine metabolic process cellular biogenic amine metabolic process triglyceride metabolic process chemical synaptic transmission synapse assembly brain development respiratory gaseous exchange learning memory long-term memory protein localization glucocorticoid metabolic process positive regulation of cell proliferation adult locomotory behavior visual learning post-embryonic development response to ionizing radiation response to lead ion regulation of gene expression positive regulation of gene expression oligodendrocyte development dendrite development proprioception sensory perception of pain spinal cord development cerebellum development ventricular system development principal sensory nucleus of trigeminal nerve development striatum development hippocampus development olfactory bulb development thalamus development cerebral cortex development neuron projection development heterochromatin assembly positive regulation of synaptic plasticity cardiolipin metabolic process response to estradiol multicellular organismal response to stress social behavior cellular response to potassium ion response to cocaine neuron maturation negative regulation of neuron apoptotic process regulation of respiratory gaseous exchange positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter phosphatidylcholine metabolic process regulation of synaptic plasticity lung alveolus development oligodendrocyte differentiation negative regulation of astrocyte differentiation regulation of synapse organization neuromuscular process controlling posture neuromuscular process sensory perception of touch response to other organism excitatory postsynaptic potential long-term synaptic potentiation positive regulation of dendritic spine development negative regulation of dendritic spine development cellular response to isoquinoline alkaloid negative regulation of locomotion involved in locomotory behavior response to alcohol regulation of action potential firing threshold positive regulation of anterograde dense core granule transport positive regulation of retrograde dense core granule transport negative regulation of dendrite extension positive regulation of dendrite extension response to bisphenol A negative regulation of respiratory gaseous exchange positive regulation of branching morphogenesis of a nerve negative regulation of primary miRNA processing
          It has to be done as per old AB suggested Products section.

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