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Product Details
A300-105A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 575 and the C-terminus (residue 615) of human Multiple Endocrine Neoplasia 1.
Conjugate
Form
liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Rat, Bovine and Dog
Target Information
Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Menin; multiple endocrine neoplasia I
Gene Aliases: AW045611; MEAI; MEN1; SCG2
UniProt ID: (Human) O00255, (Mouse) O88559
Entrez Gene ID: (Human) 4221, (Mouse) 17283
four-way junction DNA binding
Y-form DNA binding
chromatin binding
double-stranded DNA binding
protein binding
histone-lysine N-methyltransferase activity
protein binding, bridging
transcription regulatory region DNA binding
protein N-terminus binding
R-SMAD binding
DNA binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
ossification
leukocyte homeostasis
negative regulation of protein phosphorylation
osteoblast fate commitment
osteoblast development
type B pancreatic cell differentiation
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
cell cycle arrest
negative regulation of cell proliferation
response to UV
embryo development
response to gamma radiation
negative regulation of cell-substrate adhesion
chromatin modification
histone methylation
hemopoiesis
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of histone methylation
positive regulation of protein binding
regulation of activin receptor signaling pathway
histone lysine methylation
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of cell differentiation
negative regulation of osteoblast differentiation
positive regulation of osteoblast differentiation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JNK cascade
negative regulation of organ growth
embryonic skeletal system morphogenesis
negative regulation of epithelial cell proliferation
positive regulation of cell division
negative regulation of telomerase activity
palate development
maternal process involved in female pregnancy
regulation of type B pancreatic cell proliferation
response to transforming growth factor beta
negative regulation of cell cycle G1/S phase transition
mitotic cell cycle
DNA repair
brain development
decidualization
cellular response to glucose stimulus
cellular response to peptide hormone stimulus
beta-catenin-TCF complex assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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