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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide (Human) which represented a portion of the C-terminus of Menin.|
|Purification||Antigen affinity chromatography|
|Storage buffer||tris citrate/tris phosphate, pH 7-8|
|Contains||0.1% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunoprecipitation (IP)||2-10 µg/mg of lysate|
|Western Blot (WB)||1:1000-1:10,000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-21995 detects Menin in Human and Mouse samples.
PA1-21995 has been successfully used in Immunoprecipitation and Western Blot procedures.
PA1-21995 immunogen corresponds to Synthetic peptide (Human) which represented a portion of the C-terminus of Menin..
Menin is a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Two variants of the shorter transcript have been identified where alternative splicing affects the CDS. Five variants where alternative splicing takes place in the 5' UTR have also been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
menin; multiple endocrine neoplasia I
AW045611; MEAI; MEN1; SCG2