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Invitrogen

Menin Polyclonal Antibody

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View all (23) Menin antibodies

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Menin Polyclonal Antibody

Product Details

PA5-79663

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E.coli-derived human Menin recombinant protein (Position: P301-L615).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

0.9mg NaCl, 0.2mg Na2PO4, 5mg BSA

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2746778

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: HELA whole cell, 293T whole cell, SMMC whole cell, HEPA whole cell, COLO320 whole cell.

Target Information

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Menin

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Gene Aliases: AW045611; MEAI; MEN1; SCG2

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UniProt ID: (Human) O00255, (Mouse) O88559

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Entrez Gene ID: (Human) 4221, (Mouse) 17283

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Function(s)
four-way junction DNA binding Y-form DNA binding transcription regulatory region sequence-specific DNA binding DNA binding chromatin binding double-stranded DNA binding protein binding protein binding, bridging phosphoprotein binding R-SMAD binding histone-lysine N-methyltransferase activity sequence-specific DNA binding transcription regulatory region DNA binding protein N-terminus binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK cascade negative regulation of protein phosphorylation osteoblast development DNA repair chromatin organization regulation of transcription from RNA polymerase II promoter cellular response to DNA damage stimulus negative regulation of cell proliferation response to UV response to gamma radiation positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity T-helper 2 cell differentiation negative regulation of osteoblast differentiation negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cell cycle positive regulation of gene expression, epigenetic negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade ossification leukocyte homeostasis osteoblast fate commitment type B pancreatic cell differentiation chromatin remodeling transcription, DNA-templated regulation of transcription, DNA-templated cell cycle arrest embryo development negative regulation of cell-substrate adhesion chromatin modification histone methylation hemopoiesis positive regulation of histone methylation positive regulation of protein binding regulation of activin receptor signaling pathway histone lysine methylation positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cell differentiation positive regulation of osteoblast differentiation positive regulation of transcription, DNA-templated negative regulation of organ growth embryonic skeletal system morphogenesis negative regulation of epithelial cell proliferation positive regulation of cell division negative regulation of telomerase activity palate development maternal process involved in female pregnancy regulation of type B pancreatic cell proliferation response to transforming growth factor beta negative regulation of cell cycle G1/S phase transition
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