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Invitrogen
Midkine Polyclonal Antibody
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Product Details
PA5-86776
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to residues in Human MDK.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
Midkine is a retinoic acid-responsive, heparin-binding growth factor expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinomas, suggesting that it may play a role in tumorigenesis, perhaps through its effects on angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Amphiregulin-associated protein; ARAP; FLJ27379; Midgestation and kidney protein; Midkine; MK; neurite growth-promoting factor 2; Neurite outgrowth-promoting factor 2; Neurite outgrowth-promoting protein; Retanoic acid-responsive protein; retinoic acid inducible factor; Retinoic acid-induced differentiation factor; retinoic acid-responsive protein
Gene Aliases: ARAP; MDK; Mek; MK; MK1; NEGF2
UniProt ID: (Human) P21741, (Mouse) P12025, (Rat) Q9R1S9
Entrez Gene ID: (Human) 4192, (Mouse) 17242, (Rat) 81517
behavioral fear response
leukocyte chemotaxis involved in inflammatory response
T cell activation involved in immune response
positive regulation of leukocyte chemotaxis
cytoskeleton organization
negative regulation of cell adhesion
signal transduction
nervous system development
short-term memory
response to xenobiotic stimulus
response to wounding
response to hormone
negative regulation of cardiac muscle cell apoptotic process
positive regulation of epithelial to mesenchymal transition
positive regulation of macrophage chemotaxis
positive regulation of keratinocyte proliferation
positive regulation of neuron projection development
response to auditory stimulus
cell migration
dentate gyrus development
cerebellar granular layer development
hippocampus development
cerebral cortex development
cell differentiation
negative regulation of ossification
adrenal gland development
positive regulation of cell migration
defecation
regulation of chondrocyte differentiation
positive regulation of interleukin-12 production
intracellular signal transduction
tissue regeneration
negative regulation of neuron apoptotic process
estrous cycle
positive regulation of T cell differentiation
negative regulation of regulatory T cell differentiation
positive regulation of cell adhesion
positive regulation of transcription, DNA-templated
regulation of bone remodeling
oogenesis
positive regulation of oligodendrocyte differentiation
positive regulation of inflammatory response
regulation of behavior
response to glucocorticoid
positive regulation of cell division
positive regulation of cartilage development
positive regulation of smooth muscle cell chemotaxis
positive regulation of neutrophil chemotaxis
negative regulation of canonical Wnt signaling pathway
negative regulation of inflammatory response to wounding
positive regulation of inflammatory response to wounding
glial cell projection elongation
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of leukocyte cell-cell adhesion
negative regulation of epithelial cell apoptotic process
positive regulation of leukocyte adhesion to vascular endothelial cell
positive regulation of blood vessel branching
positive regulation of vascular endothelial cell proliferation
positive regulation of artery morphogenesis
positive regulation of neural precursor cell proliferation
positive regulation of hepatocyte proliferation
positive regulation of neutrophil extravasation
positive regulation of neuron migration
multicellular organism development
negative regulation of neuron death
response to drug
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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