Immunogen sequence: MEFAELIKTP RVDNVVLHRP FYPAVEGTLC LTGHHLILSS RQDNTEELWL LHSNIDAIDK RFVGSLGTII IKCKDFRIIQ LDIPGMEECL NIASSIEALS TLDSITLMYP FFYRPMFEVI EDGWHSFLPE QEFELYSSAT SEWRLSYVNK EFAVCPSYPP IVTVPKSIDD EALRKVATFR HGGRFPVLSY YHKKNGMVIM RSGQPLTGTN GRRCKEDEKL INATLRAGKR GYIIDTRSLN VAQQTRAKGG; Positive Samples: HepG2, HeLa, Jurkat, A-549, Mouse brain, Rat brain, Rat lung; Cellular Location: Cytoplasm
This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate.
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Protein Aliases: Inactive phosphatidylinositol 3-phosphatase 9; myotubularin related protein 8; Myotubularin-related protein 9
Gene Aliases: 9430075G12Rik; AA516943; AF073881; C8orf9; LIP-STYX; mMTMH3; Mtmr3; MTMR8; MTMR9