Recommended positive controls: 293T, A431, HeLa, HepG2.
Predicted reactivity: Mouse (88%), Rat (88%), Pig (95%), Sheep (94%), Rhesus Monkey (98%), Bovine (92%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The calpains including Calpain 1 (CAPN1), calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. Diseases associated with CAPN1 include Spastic Paraplegia 76, Autosomal Recessive and Spasticity.
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Protein Aliases: Calcium-activated neutral proteinase 1; calpain 1, (mu/I) large subunit; Calpain mu-type; calpain, large polypeptide L1; Calpain-1 catalytic subunit; Calpain-1 large subunit; Calpain-I; Calpain-II; CANP 1; Cell proliferation-inducing gene 30 protein; cell proliferation-inducing protein 30; Micromolar-calpain; mu-calpain; muCANP
Gene Aliases: CANP; CANP1; CANPL1; Capa-1; Capa1; CAPN1; mu-calpin; muCANP; muCL; PIG30; SPG76
Molecular Function: cysteine protease