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MuRF1/Trim63 Polyclonal Antibody
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Product Details
BS-2539R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human MuRF1/Trim63, amino acids 251-353.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ32380; iris ring finger protein; MURF 1; MURF-1; MuRF1; muscle ring finger protein 1; muscle specific ring finger protein 2; muscle-specific RING finger protein 1; OTTHUMP00000008701; ring finger protein 28; RING-type E3 ubiquitin transferase TRIM63; RNF 28; striated muscle RING zinc finger protein; TRIM 63; tripartite motif containing 63, E3 ubiquitin protein ligase; tripartite motif protein 63; tripartite motif-containing protein 63; ubiquitin ligase; unnamed protein product
Gene Aliases: CMH31; IRF; Murf; MURF1; MURF2; RF1; RNF28; SMRZ
UniProt ID: (Human) Q969Q1, (Rat) Q91Z63
Entrez Gene ID: (Human) 84676, (Rat) 140939, (Mouse) 433766
protein monoubiquitination
muscle contraction
regulation of gene expression
negative regulation of cardiac muscle hypertrophy
skeletal muscle atrophy
response to electrical stimulus involved in regulation of muscle adaptation
response to denervation involved in regulation of muscle adaptation
myotube cell development
protein ubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
innate immune response
negative regulation of glycolytic process
response to glucocorticoid
response to interleukin-1
cellular response to dexamethasone stimulus
signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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