A suggested positive control is Jurkat cell lysate.
PA5-19918 can be used with blocking peptide PEP-0044.
The PA5-19918 The immunogen is located within amino acids 220 - 270 of MYD88.
Predicted molecular ~ 35kD. In Western blot applications, this antibody has been observed to detect a band at: 35kD
Predicted species reactivity based on immunogen sequence: Pig: (100%), Sheep: (100%), Bovine: (100%), Chicken: (100%), Rat: (88%), Mouse (88%)
Myeloid differentiation Marker 88 (MyD88) is an adaptor molecule for the Toll/IL-1R and is involved in the inflammatory response induced by IL-1, IL-18 and LPS. MyD88 recruits IRAK to IL-1 receptor complex in response to IL-1. This pathway further leads to activation of NF-kB. MyD88 has a wide tissue distribution.
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Protein Aliases: mutant myeloid differentiation primary response 88; myeloid differentiation primary response gene (88); myeloid differentiation primary response gene 88; Myeloid differentiation primary response protein MyD88
Gene Aliases: MYD88; MYD88D
Molecular Function: scaffold/adaptor protein