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Invitrogen
MyD88 Polyclonal Antibody
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FIGURE: 1 / 3
MyD88 Antibody (PA5-85353) in ICC/IF
MYD88 antibody detects MYD88 protein by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 10 min. Green: MYD88 protein stained by MYD88 antibody (Product # PA5-85353) diluted at 1:100. Blue: Hoechst 33342 staining. Scale bar = 10 µm.
Product Details
PA5-85353
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human MYD88. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.93 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (88%), Rat (88%), Pig (88%), Sheep (87%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (87%).
Positive Control: MYD88-transfected 293T.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Myeloid differentiation Marker 88 (MyD88) is an adaptor molecule for the Toll/IL-1R and is involved in the inflammatory response induced by IL-1, IL-18 and LPS. MyD88 recruits IRAK to IL-1 receptor complex in response to IL-1. This pathway further leads to activation of NF-kB. MyD88 has a wide tissue distribution.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mutant myeloid differentiation primary response 88; myeloid differentiation primary response gene (88); Myeloid differentiation primary response protein MyD88
Gene Aliases: MYD88; MYD88D
UniProt ID: (Human) Q99836
Entrez Gene ID: (Human) 4615
toll-like receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
apoptotic process
inflammatory response
signal transduction
cell surface receptor signaling pathway
positive regulation of type I interferon production
positive regulation of interleukin-17 production
positive regulation of interleukin-23 production
positive regulation of interleukin-6 production
toll-like receptor 9 signaling pathway
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
regulation of inflammatory response
defense response to Gram-positive bacterium
positive regulation of NF-kappaB transcription factor activity
response to interleukin-1
3'-UTR-mediated mRNA stabilization
cellular response to mechanical stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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