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Invitrogen
Myb Polyclonal Antibody
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FIGURE: 1 / 1
Myb Antibody (PA5149657) in ChIP
ChIP Assay of Myb in K562 cells. ChIP-Exo-Seq composite graph for Myb polyclonal antibody (Product # PA5149657). Strand-specific reads (blue: forward, red: reverse) and IgG controls (black: forward, grey: reverse) are plotted against the distance from a composite set of reference binding sites. The antibody exhibits robust target enrichment compared to a non-specific IgG control and precisely reveals its structural organization around the binding site.
Product Details
PA5149657
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MYB
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: HSTTIADHTR PHGDSAPVSC LGEHHSTPSL PADPGSLPEE SASPARCMIV HQGTILDNVK NLLEFAETLQ FIDSFLNTSS NHENSD
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.
Target Information
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-myb; C-MYB protein; c-myb10A_CDS; c-myb13A_CDS; c-myb14A_CDS; c-myb8B_CDS; MYB-GATA1 fusion protein; oncogene AMV; Proto-oncogene c-Myb; RP1-32B1.1; Transcriptional activator Myb; unnamed protein product; v-myb avian myeloblastosis viral oncogene homolog
Gene Aliases: c-myb; c-myb_CDS; Cmyb; efg; MYB
UniProt ID: (Human) P10242
Entrez Gene ID: (Human) 4602
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
WD40-repeat domain binding
G1/S transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
mitotic cell cycle
response to hypoxia
in utero embryonic development
response to ischemia
regulation of transcription, DNA-templated
calcium ion transport
regulation of gene expression
skeletal muscle cell proliferation
stem cell division
myeloid cell differentiation
B cell differentiation
erythrocyte differentiation
positive regulation of collagen biosynthetic process
positive regulation of neuron apoptotic process
T-helper 2 cell differentiation
negative regulation of megakaryocyte differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
spleen development
thymus development
embryonic digestive tract development
positive regulation of smooth muscle cell proliferation
homeostasis of number of cells
positive regulation of glial cell proliferation
myeloid cell development
cellular response to hydrogen peroxide
cellular response to retinoic acid
cellular response to interleukin-6
positive regulation of transforming growth factor beta production
negative regulation of hematopoietic progenitor cell differentiation
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of hepatic stellate cell proliferation
cellular response to leukemia inhibitory factor
positive regulation of hepatic stellate cell activation
positive regulation of testosterone secretion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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