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Invitrogen
Mycobacterium tuberculosis MPT63 Polyclonal Antibody
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FIGURE: 1 / 1
Mycobacterium tuberculosis MPT63 Antibody (PA5-117613) in WB
Western Blot analysis of MPT63 using Mycobacterium tuberculosis MPT63 Polyclonal Antibody (Product # PA5-117613) at 2 µg/mL. Lane 1: Recombinant Mycobacterium tuberculosis Immunogenic protein MPT63 protein 1 µg. Lane 2: Recombinant Mycobacterium tuberculosis Immunogenic protein MPT63 protein 0.1 µg. Secondary: Goat polyclonal to rabbit IgG at 1:10,000 dilution. Predicted band size: 17 kDa. Observed band siz... View More
Product Details
PA5-117613
Product Specifications
Species Reactivity
Bacteria
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Mycobacterium tuberculosis Immunogenic protein MPT63 protein (30-159aa)
Conjugate
Form
Liquid
Concentration
4 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody has been tested in direct-ELISA
Target Information
MPT63 is a small, major secreted protein of unknown function from Mycobacterium tuberculosis that has been shown to have immunogenic properties and has been implicated in virulence. A BLAST search identified that MPT63 has homologs only in other mycobacteria, and is therefore mycobacteria specific. As MPT63 is a secreted protein, mycobacteria specific, and implicated in virulence, MPT63 is an attractive drug target against the deadliest infectious disease, tuberculosis (TB). As part of the TB Structural Genomics Consortium, the X-ray crystal structure of MPT63 was determined to 1.5-Angstrom resolution with the hope of yielding functional information about MPT63. The structure of MPT63 is an antiparallel beta-sandwich immunoglobulin-like fold, with the unusual feature of the first beta-strand of the protein forming a parallel addition to the small antiparallel beta-sheet. MPT63 has weak structural similarity to many proteins with immunoglobulin folds, in particular, Homo sapiens beta2-adaptin, bovine arrestin, and Yersinia pseudotuberculosis invasin. Although the structure of MPT63 gives no conclusive evidence to its function, structural similarity suggests that MPT63 could be involved in cell-host interactions to facilitate endocytosis/phagocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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