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Product Details
MYADM-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 200-250 on human Dual serine/threonine and tyrosine protein kinase protein (RIPK5).
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
MYADM, belonging to the MAL family, is a 322-amino acid protein having 7 hydrophobic transmembrane domains, several potential consensus sites for phosphorylation and sequence homology with the T-cell differentiation protein MAL and plasmolipin. It shares 75.8% sequence identity with mouse in the transmembrane regions and is associated with differentiation of hematopoietic cells or acute promyelocytic leukemia cells. Its expression is up-regulated in NB4 cells induced by all-trans retinoic acid whereas down regulation inhibits colony formation of bone marrow cells. MYADM could serve as a new marker for hematopoietic differentiation and is a target for diagnostic, prognostic and/or therapeutic interventions. It is known to express widely in brain and pancreatic islet cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Myeloid up-regulated protein; myeloid upregulated protein; Myeloid-associated differentiation marker; Protein SB135
Gene Aliases: D7Wsu62e; Mug; MYADM; SB135; UNQ553/PRO1110
UniProt ID: (Human) Q96S97, (Mouse) O35682, (Rat) Q6VBQ5
Entrez Gene ID: (Human) 91663, (Bovine) 506295, (Mouse) 50918, (Rat) 369016
negative regulation of protein phosphorylation
negative regulation of gene expression
regulation of cell-substrate adhesion
positive regulation of cell migration
negative regulation of actin filament polymerization
membrane raft organization
negative regulation of heterotypic cell-cell adhesion
cell-cell junction maintenance
establishment of endothelial barrier
protein targeting to plasma membrane
negative regulation of protein kinase C signaling
positive regulation of substrate adhesion-dependent cell spreading
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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