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Proteintech
Myocilin Polyclonal Antibody
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Product Details
14238-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Myocilin Fusion Protein Ag5492 (154-504 aa encoded by BC029261)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Amount
49.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EEKKRLRQE NENLARRLES SSQEVARLRR GQCPQTRDTA RAVPPGSREV STWNLDTLAF QELKSELTEV PASRILKESP SGYLRSGEGD TGCGELVWVG EPLTLRTAET ITGKYGVWMR DPKPTYPYTQ ETTWRIDTVG TDVRQVFEYD LISQFMQGYP SKVHILPRPL ESTGAVVYSG SLYFQGAESR TVIRYELNTE TVKAEKEIPG AGYHGQFPYS WGGYTDIDLA VDEAGLWVIY STDEAKGAIV LSKLNPENLE LEQTWETNIR KQSVANAFII CGTLYTVSSY TSADATVNFA YDTGTGISKT LTIPFKNRYK YSSMIDYNPL EKKLFAWDNL NMVTYDIKLS KM (154-504 aa encoded by BC029261)
Target Information
Myocilin is an extracellular protein expressed in the eye, including the retina, trabecular meshwork and ciliary body. Myocilin can form homomultimers in vivo and can also associate with components of the ECM via interactions with the Hep II domain of FibroPVRL1. In addition, myocilin interacts with myosin regulatory light chain, a component of the myosin motor protein complex. This interaction implies a role for myocilin in the actomyosin system, linking myocilin to the functional status of the trabecular meshwork (TM), which is responsible for controlling the intraocular pressure (IOP). Alterations in functions of the TM may lead to IOP elevation and development of glaucoma, a major cause of blindness. Myocilin is encoded by MYOC (also designated TIGR), a gene that maps to the GLC1A locus on chromosome 1q24. 3 and is susceptible to mutations. Mutations in the MYOC gene are specifically linked with primary open angle glaucoma (POAG), a blinding disease characterized by progressive loss of retinal ganglion cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: juvenile-onset open-angle glaucoma 1; mutated trabecular meshwork-induced glucocorticoid response protein; Myocilin; Myocilin 55 kDa subunit; myocilin protein; myocilin trabecular meshwork inducible glucocorticoid response protein; trabecular meshwork inducible glucocorticoid response protein; Trabecular meshwork-induced glucocorticoid response protein; unnamed protein product
Gene Aliases: AI957332; GLC1A; GPOA; JOAG; JOAG1; MYOC; TIGR
UniProt ID: (Human) Q99972, (Rat) Q9R1J4, (Mouse) O70624
Entrez Gene ID: (Human) 4653, (Rat) 81523, (Mouse) 17926
osteoblast differentiation
negative regulation of cell-matrix adhesion
signal transduction
skeletal muscle hypertrophy
myelination in peripheral nervous system
positive regulation of cell migration
neuron projection development
negative regulation of Rho protein signal transduction
non-canonical Wnt signaling pathway
ERBB2-ERBB3 signaling pathway
regulation of MAPK cascade
clustering of voltage-gated sodium channels
positive regulation of JNK cascade
positive regulation of stress fiber assembly
negative regulation of stress fiber assembly
positive regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
positive regulation of mitochondrial depolarization
bone development
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of phosphatidylinositol 3-kinase signaling
nerve development
non-canonical Wnt signaling pathway via JNK cascade
cellular response to nerve growth factor stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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