Immunogen sequence: RLPKVEILRS AIQYIERLQA LLSSLNQEER DLRYRGGGGP QPGVPSECSS HSASCSPEWG SALEFSANPG DHLLTADPTD AHNLHSLTSI VDS
MA1-12623 recognizes a protein of 34 kDa, identified as myogenin. Its epitope localizes between aa 158-178 of myogenin. Myogenin is a member of a family of myogenic regulatory genes, which includes MyoD, myf5 and MRF4. These genes encode a set of transcription factors, which are essential for muscle development. Expression of myogenin is restricted to cells of skeletal muscle origin. It is therefore a useful marker for tumors of the muscle lineage, being strongly expressed in alveolar rhabdomyosarcomas. This antibody can immunoprecipitate protein-DNA complex and is the antibody of choice for staining of formalin-fixed, araffin-embedded tissues.
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Protein Aliases: bHLHc3; Class C basic helix-loop-helix protein 3; Myf-4; MYF4; Myogenic factor 4; Myogenin
Gene Aliases: BHLHC3; myf-4; MYF4; MYOG
UniProt ID: (Human) P15173
Entrez Gene ID: (Human) 4656