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Invitrogen
N-Ras Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-34560
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 15 amino acid peptide near the carboxy terminus of human N-RAS
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is 293 cell lysate.
PA5-34560 can be used with blocking peptide PEP-1603.
Target Information
NRAS (GTPase NRas) is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. This protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in the gene encoding this protein are a cause of juvenile myelomonocytic leukemia (JMML) and Noonan syndrome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: N-ras protein part 4; Neuroblastoma RAS; neuroblastoma ras oncogene; neuroblastoma RAS viral (v-ras) oncogene homolog; neuroblastoma RAS viral oncogene homolog; Nras; proto-oncogene GTPase; RAS; RASN; small GTP binding protein; transforming protein N-Ras; unnamed protein product; v-ras neuroblastoma RAS viral oncogene homolog
Gene Aliases: ALPS4; CMNS; N-ras; NCMS; NRAS1; NS6; RALD1
UniProt ID: (Human) P01111, (Rat) Q04970
Entrez Gene ID: (Human) 4893, (Mouse) 18176, (Rat) 24605
regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
signal transduction
Ras protein signal transduction
positive regulation of cell proliferation
regulation of gene expression
positive regulation of interferon-gamma production
defense response to protozoan
positive regulation of angiogenesis
positive regulation of fibroblast proliferation
negative regulation of skeletal muscle tissue development
T cell receptor signaling pathway
regulation of cell cycle
myoblast differentiation
MAPK cascade
positive regulation of Ras protein signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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