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Invitrogen
N2DL4 Polyclonal Antibody
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Product Details
PA5-84180
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RAET1E. Recombinant protein control fragment (Product #RP-101432).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QFATNGEKSL LFDAMNMTWT VINHEASKIK ETWKKDRGLE KYFRKLSKGD CDHWLREFLG HWEAMPEPTV SPVNASDIHW SSSSLP
Highest antigen sequence indentity to the following orthologs: Rat - 30%, Mouse - 28%.
Target Information
This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ligand for NKG2D receptor; Lymphocyte effector toxicity activation ligand; MGC125309; N2DL-4; NKG2D ligand 4; NKG2D-ligand; RAE-1-like transcript 4; RAE1 like transcript 4; Retinoic acid early transcript 1E; RL-4; membrane glycoprotein; stress-inducible antigen; UL16 binding protein 4; UL16-binding protein 4; ULBP 4; ULBP4MGC125308
Gene Aliases: bA350J20.7; LETAL; N2DL-4; N2DL4; NKG2DL4; RAET1E; RAET1E2; RL-4; ULBP4; UNQ1867/PRO4303
UniProt ID: (Human) Q8TD07
Entrez Gene ID: (Human) 135250
positive regulation of T cell mediated cytotoxicity
immune system process
antigen processing and presentation of endogenous peptide antigen via MHC class Ib
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
immune response
natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated cytotoxicity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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