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Product Details
PA5-21099
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
0.5 µg/mL | - |
Immunocytochemistry (ICC/IF) |
10 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
An 18 amino acid peptide near the amino terminus of human N4BP1. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS |
Contains |
0.02% sodium azide |
Storage conditions |
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C |
RRID |
AB_11156399 |
Product Specific Information
A suggested positive control is Hela cell lysate.
PA5-21099 can be used with blocking peptide PEP-1213.
Target Information
Nedd4-binding partner-1 (N4BP1) is a developmentally expressed protein interactor and monoubiquitylation substrate of Nedd4, a HECT domain-containing ubiquitin ligase that mediates ubiquitylation and proteasome degradation of target proteins and may have a fundamental role to play in embryonic processes. N4BP1 can undergo Nedd4-mediated polyubiquitylation and proteosomal degradation. N4BP1 also functions as a negative regulator of AIF4 (also known as ITCH or Atrophin-1), an E3-ubiquitin ligase, by interacting with the second WW domain of AIF4 and impairing ubiquitination of substrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: N4BP1; Nedd4 binding protein 1; NEDD4-binding protein 1
Gene Aliases: AI481586; C81621; KIAA0615; N4BP1; RGD1305179
UniProt ID: (Human) O75113, (Mouse) Q6A037
Entrez Gene ID: (Human) 9683, (Rat) 291921, (Mouse) 80750
Molecular Function:
endoribonuclease
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