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Invitrogen
NACC2 Polyclonal Antibody
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Product Details
PA5-40941
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human BTBD14A (aa 30-79).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: CDVSIVVKGQ AFKAHRAVLA ASSLYFRDLF SGNSKSAFEL PGSVPPACFQ
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%
Target Information
Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BEN domain containing 9; BTB (POZ) domain containing 14A; BTB/POZ domain-containing protein 14A; MGC23427; NAC-2; NACC family member 2, BEN and BTB (POZ) domain containing; Nucleus accumbens-associated protein 2; Repressor with BTB domain and BEN domain; transcription repressor with a BTB domain and a BEN domain
Gene Aliases: BEND9; BTBD14; BTBD14A; BTBD31; NAC-2; NAC2; NACC2; RBB
UniProt ID: (Human) Q96BF6
Entrez Gene ID: (Human) 138151
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II transcription factor binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
histone deacetylase activity
protein binding
protein homodimerization activity
histone deacetylase binding
transcription, DNA-templated
positive regulation of cell proliferation
negative regulation of cell proliferation
posttranscriptional regulation of gene expression
histone deacetylation
cellular protein complex localization
negative regulation of transcription, DNA-templated
protein homooligomerization
negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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