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Proteintech
NADK Polyclonal Antibody
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Product Details
15548-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NADK Fusion Protein Ag7906 (98-446 aa encoded by BC001709)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LTWNKSPKS VLVIKKMRDA SLLQPFKELC THLMEENMIV YVEKKVLEDP AIASDESFGA VKKKFCTFRE DYDDISNQID FIICLGGDGT LLYASSLFQG SVPPVMAFHL GSLGFLTPFS FENFQSQVTQ VIEGNAAVVL RSRLKVRVVK ELRGKKTAVH NGLGEKGSQA AGLDMDVGKQ AMQYQVLNEV VIDRGPSSYL SNVDVYLDGH LITTVQGDGV IVSTPTGSTA YAAAAGASMI HPNVPAIMIT PICPHSLSFR PIVVPAGVEL KIMLSPEARN TAWVSFDGRK RQEIRHGDSI SITTSCYPLP SICVRDPVSD WFESLAQCLH WNVRKKQAHF EEEEEEEEEG (98-446 aa encoded by BC001709)
Target Information
NADK (Nicotinamide Adenine Dinucleotide Kinase) is an enzyme crucial in the regulation of intracellular NADP+ levels, which are necessary for metabolic processes such as fatty acid and DNA synthesis. The human NADK gene is located on chromosome 1p36.33 and encodes a protein that primarily functions in the cytoplasm. NADK catalyzes the phosphorylation of NAD+ to NADP+, playing a significant role in maintaining the cellular redox state. Structurally, human NADK forms a dimeric organization, as revealed by its crystal structure, and includes four subunits (chains A-D) with specific colors indicating different chains. The enzyme's activity is regulated post-translationally, but its pathophysiological significance in humans remains underexplored. Multiple orthologs of the NADK gene are present in various organisms, illustrating its evolutionary conservation and importance across different species.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ13052; NAD kinase; Poly(P)/ATP NAD kinase; ppnk; Putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase)
Gene Aliases: 4432404C02Rik; BC004012; dJ283E3.1; NADK
UniProt ID: (Human) O95544, (Mouse) P58058
Entrez Gene ID: (Human) 65220, (Rat) 100125370, (Mouse) 192185
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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