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Immunogen sequence: LTWNKSPKS VLVIKKMRDA SLLQPFKELC THLMEENMIV YVEKKVLEDP AIASDESFGA VKKKFCTFRE DYDDISNQID FIICLGGDGT LLYASSLFQG SVPPVMAFHL GSLGFLTPFS FENFQSQVTQ VIEGNAAVVL RSRLKVRVVK ELRGKKTAVH NGLGEKGSQA AGLDMDVGKQ AMQYQVLNEV VIDRGPSSYL SNVDVYLDGH LITTVQGDGV IVSTPTGSTA YAAAAGASMI HPNVPAIMIT PICPHSLSFR PIVVPAGVEL KIMLSPEARN TAWVSFDGRK RQEIRHGDSI SITTSCYPLP SICVRDPVSD WFESLAQCLH WNVRKKQAHF EEEEEEEEEG (98-446 aa encoded by BC001709)
The human trans-activation response (TAR) RNA binding protein 1 (TRBP1) was initially identified as a protein that binds to the HIV-1 TAR RNA and activates the long terminal repeat (LTR) expression in the absence and presence of the viral trans-activator Tat. This binding is enhanced by the presence of co-factors such as elongation factor 1-a (EF-1-a), polypyrimidine tract-binding protein (PTB), and the chaperonin-like protein stimulator of TAR RNA-binding proteins (SRB). TRBP1 may act to disengage RNA polymerase II from TAR during transcriptional elongation if the RNA polymerase stalls at the TAR during transcriptional elongation.
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Protein Aliases: FLJ13052; NAD kinase; Poly(P)/ATP NAD kinase; ppnk; Putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase)
Gene Aliases: 4432404C02Rik; BC004012; dJ283E3.1; NADK
Molecular Function: nucleotide kinase