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Invitrogen
NAIP Polyclonal Antibody
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FIGURE: 1 / 2
NAIP Antibody (PA5150104) in IHC (P)
Immunohistochemistry analysis of NAIP in paraffin-embedded Mouse Placenta tissue. Samples were incubated with NAIP Polyclonal (Product # PA5150104) antibody using a dilution of 10 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG (2 µg/mL) and DAB.
Product Details
PA5150104
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Neuronal Apoptosis Inhibitory Protein (NAIP) (Leu500-Glu759)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Neuronal apoptosis inhibitor protein (NAIP) was the first human inhibitor of apoptosis protein (IAP) identified and was discovered by its association with the neurodegenerative disorder spinal muscular atrophy. Members of the IAP family contain one to three copies of an approximately 70 amino acid motif termed baculovirus IAP repeat (BIR); these BIRs promote protein-protein interactions with various caspases such as caspase-3, -7, and -9 as well as members of the TRAF family of signal molecules (reviewed in 3). Unlike other IAPs however, NAIP requires ATP to bind caspase-9 and is not inhibited by the IAP-inhibiting molecule Smac/DIABLO, suggesting that NAIP is unique among the IAPs in its regulation of its activity. Finally, although only one human NAIP protein has been identified, other shorter NAIP mRNA transcripts have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: baculoviral IAP repeat-containing 1a; Baculoviral IAP repeat-containing protein 1a; FLJ18088; FLJ42520; FLJ58811; Neuronal apoptosis inhibitory protein 1
Gene Aliases: AV364616; Birc1a; D13Lsd1; Naip; Naip-rs1; Naip1
UniProt ID: (Mouse) Q9QWK5
Entrez Gene ID: (Mouse) 17940
apoptotic process
regulation of signal transduction
negative regulation of peptidase activity
protein ubiquitination
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to estrogen stimulus
inhibition of cysteine-type endopeptidase activity involved in apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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