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|Tested species reactivity||Human, Mouse, Primate, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide that corresponds to a region surrounding Gly1081 of human NALP1 protein|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
It is not recommended to aliquot this antibody.
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
caspase recruitment domain protein; caspase recruitment domain protein 7; caspase recruitment domain-containing protein 7; death effector filament-forming Ced-4-like apoptosis protein; NACHT, leucine rich repeat and PYD (pyrin domain) containing 1; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD containing protein 1; NACHT/LRR/pyrin domain-containing protein 1; NLR family protein 1; NLR family, pyrin domain containing 1; NLR family, pyrin domain containing 1A; nucleotide-binding domain and caspase recruitment domain; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1; resistant anthrax lethal toxin
CARD7; CIDED; CLR17.1; DEFCAP; DEFCAP-L/S; Gm14; Gm15; KIAA0926; NAC; NALP1; Nalp1a; NLRP1; Nlrp1a; PP1044; SLEV1; VAMAS1