A suggested positive control is human brain tissue lysate.
PA5-21025 can be used with blocking peptide PEP-1139.
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1-b, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1-b processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.
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Protein Aliases: CLR11.1, NALP10, NOD8, PAN5, PYNOD; NACHT, leucine rich repeat and PYD containing 10; NACHT, LRR and PYD domains-containing protein 10; NLR family, pyrin domain containing 10; Nucleotide-binding oligomerization domain protein 8; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10
Gene Aliases: CLR11.1; NALP10; NLRP10; NOD8; PAN5; PYNOD
UniProt ID: (Human) Q86W26
Entrez Gene ID: (Human) 338322