|Western Blot (WB)||1.0-2 µg/ml|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (493 REVQRLLEVKEQEGNDE 509) of NALP10 protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
NALP10, a member of the NALP protein family, is reported to have a regulatory role in the innate immune system and forms a large signal-induced multiprotein complex, the inflammasome, which activates the pro-inflammatory caspases, caspase-1 and caspase-5. Unlike other members of the family NALP10 lacks the LRR (leucine rich repeat) region but contains a DAPIN domain and a NACHT domain. Immunoprecipitation reports suggest that NALP10 interacted with ASC, CASP1, and IL-1B and inhibits NF-kB activation, CASP1/caspase-1-dependent IL-1B secretion and apoptosis induced by ASC (PYCARD) in a dose-dependent manner. Expression of NALP10 is enhanced by stimulation with lipopolysaccharide. Experiments with NALP10 suggest that it acts as a multifunctional negative regulator of inflammation and apoptosis. Wide expression of NALP10 is reported with highest levels in heart, brain and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CLR11.1; leucine rich repeat and PYD containing 10; leucine rich repeat and pyrin domain containing 10; LRR and PYD domains-containing protein 10; NACHT; NACHT, leucine rich repeat and PYD containing 10; NACHT, LRR and PYD containing protein 10; NACHT, LRR and PYD domains-containing protein 10; NACHT/LRR/pyrin domain-containing protein 10; NALP10; neuronal apoptosis inhibitor protein 10; NLR family, pyrin domain containing 10; NOD8; nucleotide-binding oligomerization domain; Nucleotide-binding oligomerization domain protein 8; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10; PAN5; PYNOD
Gene Aliases: 6430548I20Rik; CLR11.1; NALP10; Napl10; NLRP10; NOD8; PAN5; PYNOD
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.