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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (467 PNYLIPSGSREYKEKRE 483) of NALP11 protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
NALP11 is a 1033 amino acid containing cytoplasmic protein belonging to the NLRP family with a DAPIN domain, six LRR (leucine-rich) repeats and a NACHT domain. Reports suggest that it is a short NALP involved in inflammation potential. NALP proteins are implicated in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes. The DAPIN domain is necessary and sufficient for suppression of NF-kappa B activation induced by TNF and for inducing IL-1B secretion in collaboration with Caspase-1. It is involved in interaction with PYCARD.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CLR19.6; leucine rich repeat and PYD containing 11; leucine rich repeat and pyrin domain containing 11; LRR and PYD containing protein 11; LRR and PYD domains-containing protein 11; NACHT; NACHT, leucine rich repeat and PYD containing 11; NALP11; NLR family, pyrin domain containing 11; NOD17; nucleotide-binding oligomerization domain; nucleotide-binding oligomerization domain protein 17; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 11; PAAD- and NACHT-containing protein 10; PAAD- and NACHT-containing protein 10B; PAAD-and NACHT domain-containing protein 10; PAN10; PYPAF6; PYPAF7; PYRIN-containing APAF1-like protein 6
CLR19.6; NALP11; NLRP11; NOD17; PAN10; PYPAF6; PYPAF7