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Invitrogen
NALP2 Polyclonal Antibody
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FIGURE: 1 / 1
NALP2 Antibody (PA5-142554) in WB
Western Blot analysis of NALP2 in HEK293 lysate (10 µg protein in RIPA buffer) using NALP2 Polyclonal Antibody (Product # PA5-142554) at 1 µg/mL. Lane A: HEK293 lysate over expressing Human NALP2 with DYKDDDDK tag probed with NALP2 Antibody. Lane B: Mock-transfected HEK293 probed with NALP2 Antibody. Lane C: HEK293 lysate over expressing Human NALP2 with DYKDDDDK tag probed with anti-DYKDDDDK Tag (1:1,000). Primary incubations were for 1 hour. Detected by chemiluminescence.
Product Details
PA5-142554
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-TEKHHPWAERPSSHD.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:4,000.
Target Information
NALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli. Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR), and pyrin-containing domain (PYD). This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1-b-processing activity and is thought to function as a modulator of NF-kappa-B and procaspase-1 activation in macrophages. It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for NALP2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ20510; NACHT, leucine rich repeat and PYD containing 2; NACHT, LRR and PYD containing protein 2; NACHT, LRR and PYD domains-containing protein 2; NLR family, pyrin domain containing 2; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2; Nucleotide-binding site protein 1; PYRIN domain and NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2
Gene Aliases: CLR19.9; NALP2; NBS1; NLRP2; PAN1; PYPAF2
UniProt ID: (Human) Q9NX02
Entrez Gene ID: (Human) 55655
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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