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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 13 amino acid peptide near the center of human NALP4.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is K562 cell lysate.
PA5-21020 can be used with blocking peptide PEP-1134.
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-kappa-B induction by TNF-a and IL-1-b, suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-kappa-B induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-alpha and IKK-beta, suggesting that NALP4 is critical in modulating NF-kappa-B activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
cancer/testis antigen 58; CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2; NACHT, leucine rich repeat and PYD containing 4; NACHT, leucine rich repeat and PYD containing 4A; NACHT, LRR and PYD containing protein 4; NACHT, LRR and PYD domains-containing protein 4A; NACHT/LRR/pyrin domain-containing protein 4; NLR family, pyrin domain containing 4; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 4; PAAD and NACHT-containing protein 2; PYRIN and NACHT-containing protein 2; PYRIN-containing APAF1-like protein 4; ribonuclease inhibitor 2
CLR19.5; CT58; E330021B02; E330028A19Rik; Nalp-eta; Nalp-ita; NALP4; Nalp4a; NLRP4; Nlrp4a; PAN2; PYPAF4; RNH2